Netarsudil

Overview

Netarsudil (AR-13324) is a competitive inhibitor of Rho-associated protein kinases ( ROCK I and ROCK II ) and a reversible inhibitor of the norepinephrine transporter ( NET ). Netarsudil reduces intraocular pressure by inhibiting ROCK , causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil is mainly used in the study of ocular hypertension and primary open-angle glaucoma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Monoamine Transporter | Products > Signaling Pathways > ROCK

Product Information

• Catalog No.: HY-12798
• CAS No.: 1254032-66-0
• Molecular Formula: C28H27N3O3
• Molecular Weight: 453.53
• Purity: 99.94%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.51 mM); Clear solution
• Availability: In-stock

Source

Original product source