MLS1547

CAS No.：315698-36-3
Grade：99.94%
Formula：C19H19ClN4O
M.W.：354.83
Solvent：≥ 1.25 mg/mL (3.52 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

MLS1547 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist ( K i =1.2 μM). MLS1547 stimulates D2R G protein-mediated signaling ( EC 50 =0.37 μM in a calcium mobilization assay). MLS1547 acts as an antagonist for dopamine (DA)-stimulated β-arrestin recruitment to the D2R (IC 50 =9.9 μM).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Depression | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Dopamine Receptor

Product Information

Catalog No.: HY-128121
CAS No.: 315698-36-3
Molecular Formula: C19H19ClN4O
Molecular Weight: 354.83
Purity: 99.94%
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Solubility: ≥ 1.25 mg/mL (3.52 mM); Clear solution
Availability: In-stock

Source

Original product source

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