(R)-IDO/TDO-IN-1 (compound 25) is an indoleamine-2,3-dioxygenase ( IDO ) inhibitor, with good pharmacokinetic properties. (R)-IDO/TDO-IN-1 exhibits anti-tumor activity in MC38 xenograft model. (R)-IDO/TDO-IN-1 shows synergistic effect with anti-PD-1 monoclonal antibody (SHR-1210).
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