SB24011

Overview

SB24011 is a STING modulator and a TRIM29-STING protein-protein interaction inhibitor. SB24011 blocks TRIM29-induced K48 -linked specific ubiquitination by binding to STING , thereby upregulating intracellular STING protein levels. SB24011 enhances inflammatory cytokine expression and STING-mediated immune responses, and exhibits abscopal antitumor activity that promotes tumor regression and activates T cell infiltration. When combined with STING agonists or anti- PD1 antibodies, SB24011 synergistically enhances antitumor responses. SB24011 is suitable for research related to colon cancer and melanoma.

Application

Products | Products > Disease Areas > Cancer Immunology | Products > Disease Areas > Immunotherapy for Colorectal Cancer | Products > Disease Areas > Metastatic Melanoma | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Melanoma | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > STING

Product Information

• Catalog No.: HY-128481
• CAS No.: 1497415-41-4
• Molecular Formula: C34H38N4O7
• Molecular Weight: 614.69
• Purity: 99.7%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source