SAG dihydrochloride

Overview

SAG dihydrochloride is a potent Smoothened ( Smo ) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine ( HY-17024 ) inhibition of Smo .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Smo

Product Information

• Catalog No.: HY-12848C
• CAS No.: 2702366-44-5
• Molecular Formula: C28H30Cl3N3OS
• Molecular Weight: 562.98
• Purity: 98.23%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution
• Availability: In-stock

Source

Original product source