EP2 receptor agonist 2 (compound 18a) is a potent and selective G protein-biased EP2 receptor agonist ( hEP2 G protein EC 50 = 13 nM, hEP2 β arrestin EC 50 > 10000 nM). EP2 receptor agonist 2 exhibits excellent selectivity over hEP1/3/4 , hIP and hFP ( EC 50 s > 10000 nM).
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