ARS-1323-alkyne

Overview

ARS-1323-alkyne is a covalent inhibitor probe that covalently binds to the Switch-II pocket (S-IIP) of the KRAS G12C mutant protein. ARS-1323-alkyne visualizes the covalent modification of KRAS G12C and quantitatively measures the binding efficiency of the inhibitor to the target. ARS-1323-alkyne can be used to validate the target occupancy of KRAS G12C inhibitors and the synergistic mechanism of combination therapy.

Application

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Product Information

• Catalog No.: HY-128522
• CAS No.: 2436544-27-1
• Molecular Formula: C28H27ClF2N6O3
• Molecular Weight: 569.00
• Purity: 99.59%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2.08 mg/mL (3.66 mM); Clear solution
• Availability: In-stock

Source

Original product source