DHW-208

Overview

PI3K-IN-4 is a potent Pan-PI3K inhibitor. PI3K-IN-4 has high activity for three PI3K isoforms with the IC 50 values of picomole. PI3K-IN-4 shows superior inhibitory activity against PI3Kα ( IC 50 = 0.20 nM), PI3Kβ ( IC 50 = 2.99 nM), PI3Kδ ( IC 50 = 0.48 nM) and PI3Kγ ( IC 50 = 0.58 nM) and has no significant activity against EGFR . PI3K-IN-4 inhibits cancer cell growth though PI3K/Akt signaling pathway, leading to the inhibition of colony formation and the induction of apoptosis . PI3K-IN-4 can be used for lung, colon and breast cancer research.

Application

Products | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-128633
• CAS No.: 2269470-35-9
• Molecular Formula: C25H21F2N7O4S
• Molecular Weight: 553.54
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source