EN6

EN6
  • CAS No.:1808714-73-9
  • Grade:99.42%
  • Formula:C19H14F2N4O2
  • M.W.:368.34
  • Solvent:10 mg/mL (27.15 mM); Suspended solution; Need ultrasonic

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

Overview

EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase . EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag , leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy . EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Autophagy

Product Information

  • Catalog No.: HY-128892
  • CAS No.: 1808714-73-9
  • Molecular Formula: C19H14F2N4O2
  • Molecular Weight: 368.34
  • Purity: 99.42%
  • Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
  • Solubility: 10 mg/mL (27.15 mM); Suspended solution; Need ultrasonic
  • Availability: In-stock

Source

Original product source


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