SX-517

Overview

SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca 2+ flux (IC 50 =38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC 50 =60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for inflammation suppression, in both humanized polymorphonuclear (PMN) cells and in murine model.

Application

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Product Information

• Catalog No.: HY-12927
• CAS No.: 1240494-13-6
• Molecular Formula: C19H16BFN2O3S
• Molecular Weight: 382.22
• Purity: 99.90%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 3.75 mg/mL (9.81 mM); Clear solution
• Availability: In-stock

Source

Original product source