Bisindolylmaleimide VIII acetate

Overview

Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C ( PKC ) inhibitor with an IC 50 of 158 nM for rat brain PKC . Bisindolylmaleimide VIII acetate has IC 50 s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-β I , PKC-β II , PKC-γ, PKC-ε, respectively. Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.

Application

Products | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PKC | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-129624A
• CAS No.: 138516-31-1
• Molecular Formula: C26H26N4O4
• Molecular Weight: 458.51
• Purity: 99.68%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (4.54 mM); Clear solution
• Availability: In-stock

Source

Original product source