CLH304a

Overview

CLH304a (compound 14) is a specific and noncompetitive GABA B receptor negative allosteric modulator (NAM). CLH304a decreases GABA-induced IP3 production with an IC 50 of 37.9 μM. CLH304a has no effect on other GPCR Class C members such as mGluR1 , mGluR2 , and mGluR5 . CLH304a acts on the heptahelical domain of GB2 subunits and non-competitively inhibits the effect of agonists with inverse agonist properties. CLH304a inhibits Baclofen ( HY-B0007 )-induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABA B receptor.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > GABA Receptor | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-129636
• CAS No.: 1611483-29-4
• Molecular Formula: C18H24O4
• Molecular Weight: 304.38
• Purity: 99.64%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (8.21 mM); Clear solution
• Availability: In-stock

Source

Original product source