CMLD012612

Overview

CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC 50 value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) and possesses potent anti-neoplastic activity.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Eukaryotic Initiation Factor (eIF)

Product Information

• Catalog No.: HY-129767
• CAS No.: 2368900-35-8
• Molecular Formula: C31H33N3O7
• Molecular Weight: 559.61
• Purity: 99.98%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Source

Original product source