MRGPRX1 agonist 1

Overview

MRGPRX1 agonist 1 is a highly potent MRGPRX1 agonist ( EC 50 =50 nM) with greater than 50-fold selectivity for δ, μ, and κ opioid receptors. MRGPRX1 agonist 1 is inactive against MRGPRC11. MRGPRC11 inhibits high voltage-activated (HVA) Ca 2+ currents, reduces neurotransmitter release, and mitigates nociceptive transmission in the spinal cord. MRGPRX1 agonist 1 is useful for the study of chronic pain, especially neuropathic pain.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Mas-related G-protein-coupled Receptor (MRGPR)

Product Information

• Catalog No.: HY-130118
• CAS No.: 2377379-39-8
• Molecular Formula: C23H21N3O4S
• Molecular Weight: 435.50
• Purity: 99.95%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (4.78 mM); Clear solution
• Availability: In-stock

Source

Original product source