PDDHV is a calcium absorption inducer and may achieve 45Ca 2+ influx by stimulating vanillic acid receptor VR1. PDDHV induces 45Ca 2+ uptake ( EC 50 : 70 nM) in rat dorsal root ganglion neurons (expressing native vanilloid receptors) and calcium mobilization ( EC 50 : 125 nM) in VR1-transfected CHO cells. PDDHV also inhibits [3H]-resiniferatoxin (RTX) binding to the dorsal root ganglion membrane in rats.
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