RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC 50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC 50 s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC 50 of 1.1 μM.
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