SB 206553 is a 5-HT 2C inverse agonist. SB 206553 can attenuate methamphetamine-seeking in rats. SB 206553 has activity for 5-HT2 receptor ligands in HEK-293 or CHO-K1 cells expressing human recombinant 5-HT2 receptors with pKi values of 5.6 nM (5-HT 2A ), 7.7 nM (5-HT 2B ) and 7.8 nM (5-HT 2C ), respectively. SB 206553 can be used for the research of psychostimulant abuse disorders.
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