YS-370

Overview

YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein ( P-gp ). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4 . YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > P-glycoprotein

Product Information

• Catalog No.: HY-132866
• CAS No.: 2470908-79-1
• Molecular Formula: C37H35BrN4O3
• Molecular Weight: 663.60
• Purity: 98.07%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source