EP4 receptor antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist for cancer immunotherapy . EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC 50 s of 6.1 nM and 16.2 nM, respectively. IC 50 s >10 μM for human EP1, EP2,and EP3 receptors.
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