Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC 50 s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively.
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