(+)SHIN2

Overview

(+)SHIN2 is a serine hydroxymethyltransferase ( SHMT ) inhibitor, whose target can be traced with 13 C-serine. (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate ( HY-14519 ). (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > SHMT

Product Information

• Catalog No.: HY-134978A
• CAS No.: 3056942-19-6
• Molecular Formula: C23H26N4O3
• Molecular Weight: 406.48
• Purity: 99.30%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution
• Availability: In-stock

Source

Original product source