Cutamesine (SA4503) dihydrochloride is a potent and selective sigma 1 receptor agonist with an IC 50 of 17.4 nM in guinea pig brain membranes. Cutamesine dihydrochloride shows >100-fold less affinity for the sigma 2 receptor (IC 50 of 1784 nM). Cutamesine dihydrochloride has antidepressant effects.
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