DB1976 dihydrochloride

Overview

DB1976 dihydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 dihydrochloride potently inhibits PU.1 binding ( IC 50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, K D of 12 nM) in vitro. DB1976 dihydrochloride has apoptosis -inducing effect.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-135797A
• CAS No.: 2369663-93-2
• Molecular Formula: C20H18Cl2N8Se
• Molecular Weight: 520.28
• Purity: 98.0%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
• Solubility: 2.5 mg/mL (4.81 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source