Cantharidic acid is a selective inhibitor for protein phosphatase 2 ( PP2A ) and protein phosphatase 1 ( PP1 ). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway.
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