Sp-8-Cl-cAMPS is an analog of cAMP ( HY-B1511 ) and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC 50 of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII , with K a of 0.25 and 3.2 μM.
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