RK-582

Overview

RK-582 is a tankyrase inhibitor, antitumor agent, and orally bioavailable growth inhibitor, with an IC 50 of 36.1 nM against human tankyrase-1 and an IC 50 of 39.2 nM against human tankyrase-2 . In APC-mutated colorectal cancer cells, the sensitivity to RK-582 correlates with the level of active β-catenin , while drug resistance associates with PIK3CA mutation. RK-582 can be used for the research of colorectal cancer .

Application

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Product Information

• Catalog No.: HY-137849
• CAS No.: 2171388-28-4
• Molecular Formula: C27H35FN6O3
• Molecular Weight: 510.60
• Purity: 98.05%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.90 mM); Clear solution
• Availability: In-stock

Source

Original product source