JKE-1674

Overview

JKE-1674 is an orally active glutathione peroxidase 4 ( GPX4 ) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors.

Application

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Product Information

• Catalog No.: HY-138153
• CAS No.: 2421119-60-8
• Molecular Formula: C20H20Cl2N4O4
• Molecular Weight: 451.30
• Purity: 99.97%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: 5 mg/mL (11.08 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source