2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine ( HY-17026 ). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells.
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