BM-1074 is a potent and specific Bcl-2/Bcl-xL inhibitor with K i values of < 1 nM and IC 50 values of 1.8 nM and 6.9 nM for Bcl-2 and Bcl-xL , respectively. BM-1074 induces apoptosis , and exhibits antiproliferative activity against four small-cell lung cancer cell lines (H146, H1963, H187 and H1417) with IC 50 values of 1-2 nM.
Products | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Apoptosis
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