PAD3-IN-1 (compound 14b) is an inhibitor of protein arginine deiminase ( PAD ) and is more than 10-fold more selective for PAD3 than PAD 1 , 2 , and 4 . The IC 50 values of PAD3-IN-1 for PAD 1 , 2 , 3 , and 4 are 120, 27.5, 4.5, and 30.5 μM, respectively. And PAD3 is a PAD isoform associated with neurodegenerative responses to spinal cord injury, and PAD3-IN-1 could be used to study PAD-related neurological diseases.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Protein Arginine Deiminase
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