Clorgyline (M&B 9302) is an orally active, blood-brain barrier permeable and selective monoamine oxidase A ( MAO-A ) inhibitor. Clorgyline's selective inhibition of MAO-A leads to reduced metabolism of neurotransmitters such as serotonin (5-hydroxytryptamine), which accumulates in the brain. Clorgyline can be used in the study of depression and neurodegenerative diseases.
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