SCP1-IN-2 (Compound SH T-65) is a potent and selective covalent inhibitor against SCP1 . SCP1-IN-2 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-2 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity.
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