Pinacidil (P-1134) is a potent activator of ATP-sensitive potassium channel . Pinacidil is an antihypertensive agent hyperpolarizes vascular smooth muscle by opening K + channels . Pinacidil enhances K + -efflux in smooth muscle. Pinacidil has vasorelaxant properties. Pinacidil is able to inhibit spontaneous tone and of reducing agonist induced contractions. Pinacidil can be studied in research area such as cardiovascular diseases.
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