A2AAR/HDAC-IN-2 is a potent A 2A AR/HDAC dual inhibitor, with good binding affinity for A 2A AR ( K i =10.3 nM) and good inhibitory activity against HDAC1 ( IC 50 =18.5 nM). A2AAR/HDAC-IN-2 can be used in study of antitumor.
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