HDAC1/2 and CDK2-IN-1 (compound 14d) is a potent HDAC1 , HDAC2 and CDK2 dual inhibitor, with IC 50 values of 70.7, 23.1 and 0.80 μM, respectively. HDAC1/2 and CDK2-IN-1 can block the cell cycle and induce apoptosis . HDAC1/2 and CDK2-IN-1 exhibits desirable in vivo antitumor activity.
Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Apoptosis
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