TRK/ALK-IN-1 (compound 21) is a potent and dual inhibitor of TRK and ALK . TRK/ALK-IN-1 in the enzymatic assays is in good accordance with anti-proliferative activity with IC 50 values of 2.2, 9.3 and 38 nM towards TRKA , ALK WT and ALK L1196M , respectively. TRK/ALK-IN-1 has the potential for the research of cancer diseases.
Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Trk Receptor | Products > Signaling Pathways > Anaplastic lymphoma kinase (ALK)
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