KIRA9 is a potent IRE1 inhibitor ( IC 50 =4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis .
Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Others | Products > Signaling Pathways > IRE1 | Products > Signaling Pathways > Apoptosis
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