MAX-40279

Overview

MAX-40279 is a dual and orally active inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 is also effective against the FLT3 mutants such as FLT3 D835Y , suggesting that it can overcome resistance to Quizartinib ( HY-13001 ) and Sorafenib ( HY-10201 ). MAX-40279 inhibits NDRG1 phosphorylation at Ser330 and suppresses endothelial-to-mesenchymal transition (EndMT). MAX-40279 can be used for the research of acute myelogenous leukemia (AML).

Application

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Product Information

• Catalog No.: HY-145723
• CAS No.: 2070931-57-4
• Molecular Formula: C22H23FN6OS
• Molecular Weight: 438.52
• Purity: 97.04%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.70 mM); Clear solution
• Availability: In-stock

Source

Original product source