AGI-43192

Overview

AGI-43192 is a potent and orally active inhibitor of methionine adenosyltransferase 2A ( MAT2A ) that limitedly penetrates the blood-brain barrier. AGI-43192 exhibits inhibitory activitity against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC 50 s of 32 and 14 nM. AGI-43192 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-43192 can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer .

Application

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Product Information

• Catalog No.: HY-145777
• CAS No.: 2377491-54-6
• Molecular Formula: C23H16ClF3N6O
• Molecular Weight: 484.86
• Purity: 99.47%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 8.33 mg/mL (17.18 mM); Clear solution
• Availability: In-stock

Source

Original product source