β-catenin-IN-3

Overview

β-catenin-IN-3 (Compound C2) is a selective β-catenin inhibitor. β-catenin-IN-3 binds to allosteric site on the surface of β-catenin with K D calculated at 54.96 nM. β-catenin-IN-3 selectively inhibits β-catenin via targeting a cryptic allosteric modulation site, lowers its cellular load. β-catenin-IN-3 significantly reduces viability of β-catenin driven cancer cells, and triggers β-catenin degradation via proteasome system in β-catenin-overexpressing cancer cells.

Application

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Product Information

• Catalog No.: HY-147007
• CAS No.: 1005288-15-2
• Molecular Formula: C19H20Br2N2OS
• Molecular Weight: 484.25
• Purity: 95.64%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (5.16 mM); Clear solution
• Availability: In-stock

Source

Original product source