AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC 50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis . AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK . AKT-IN-12 can be used for researching leukemia.
Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Apoptosis
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