ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC 50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K , with IC 50 values of 47, 663 and 5131 nM, respectively.
Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > ATM/ATR | Products > Signaling Pathways > DNA-PK | Products > Signaling Pathways > PI3K
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