5-Benzyloxytryptamine (5-BT) is a selective partial agonist for 5-hydroxytryptamine 1D/1B ( 5-HT 1 D/ 1 B ) receptors with an IC 50 value of 40 nM for bovine caudate 5-HT 1 D and reduced affinity for other receptors (5-HT 2 IC 50 >470 nM). 5-Benzyloxytryptamine inhibits adenylate cyclase to decrease neurotransmitter release and downregulate cAMP signaling. 5-Benzyloxytryptamine is promising for research of neurotransmitter imbalance-related disorders like migraine.
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