Vemtoberant is a β 3 -adrenergic receptor inhibitor with a human K i of 8.2 nM, and exhibits 400- to 600-fold selectivity over human β 1 -AR and β 2 -AR . Vemtoberant attenuates β 3 -AR -mediated cardiac inhibition. Vemtoberant can be used for the research of systolic heart failure.
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