ABCB1-IN-1 (compound 3) is a potent ABCB1 inhibitor. ABCB1-IN-1 induces cell apoptosis . ABCB1-IN-1 bearing 1-benzylimidazole has IC 50 values of 1.26 μM and 2.21 μM for Colo205 and Colo320 cells, respectively.
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