RIPK3-IN-3

Overview

RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 ( IC 50 =10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis , while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis . RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Obesity | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Mixed Lineage Kinase | Products > Signaling Pathways > RIP kinase

Product Information

• Catalog No.: HY-149393
• CAS No.: 3052303-53-1
• Molecular Formula: C16H11N5S
• Molecular Weight: 305.36
• Purity: 95.98%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution
• Availability: In-stock

Source

Original product source