MC-1-F2 is a FOXC2 inhibitor. MC-1-F2 shows a binding affinity ( K d ) of 26 μM for full-length FOXC2. MC-1-F2 reduces epithelial-mesenchymal transition ( EMT ) markers in breast cancer cells, suppresses cancer stem cell (CSC) properties and reduces invasiveness in castration-resistant prostate cancer (CRPC) cells. MC-1-F2 can be used for the study of CRPC and breast cancer .
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