PolQi2

Overview

PolQi2 is a PolΘ inhibitor that targets and inhibits alt-EJ (alternative end-joining) repair by inhibiting the helicase domain at the N-terminus of PolΘ . PolQi2 enhances the precision and integration efficiency of gene editing at different loci and in various cell lines. Furthermore, the combined use of PolQi2 with DNA-PK inhibitors reduces the off-target effects of Cas9. PolQi2 can be used in gene editing research.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Others | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-150279
• CAS No.: 2565638-16-4
• Molecular Formula: C21H16ClN5O3S
• Molecular Weight: 453.90
• Purity: 98.91%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (5.51 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source