FGFR-IN-8

Overview

FGFR-IN-8 (Compound 17a) is a highly potent and orally active pan FGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC 50 values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4, respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities.

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > FGFR | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-150652
• CAS No.: 2640217-64-5
• Molecular Formula: C27H31Cl2N9O2
• Molecular Weight: 584.50
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source