CHF-6366 is a potent M3 muscarinic antagonist and β2-adrenergic receptors agonist with pK i values of 10.4 and 11.4, respectively. CHF-6366 is also a weak calcium channel inhibitor ( IC 50 ~50 μM). CHF-6366 inhibits bronchoconstriction in guinea pigs. CHF-6366 can be used to research chronic obstructive pulmonary disease (COPD).
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